The
first pathophysiology department
in Bulgaria was established
at the Medical University
of Plovdiv in 1947. It was
found and headed by Prof.
L. Telcharov, DMSc. He was
taught by prof. Mollov,
prof. Klisurov and the first
teacher in pathophysiology
in Bulgaria – Assoc. prof.
Minko Dobrev. Prof. L. Telcharov
was the head of the department
from 1947 till 1963. His
successors as head of Pathophysiology
Dept. in the next 60 years
were as follows: Prof. N.
Boshev, DMSc – 1963 – 1965,
Prof. Iv. Kirin, DMSc –
1965 – 1989, Prof D. Mitkov,
DMSc – 1989 – 2001, Prof.
D. Iluchev, DMSc – 2001
– 2004 and Assoc. Prof.
St. Kostianev, DMSc – from
2004.
The first assistant professors
at Pathophysiology Dept.
were: Dr N. Gajdadzhieva,
Dr M. Todorova and Dr J.
Pantev. In the early 50s
Dr B. Kjutjukchiev, PhD,
Dr V. Zozikov, PhD, Dr M.
Cholakov, Dr Ivan Kirin,
PhD, Dr N. Nikolov, PhD,
joined the department. As
a result of developing more
detailed education in pathophysiology
and the establishment of
functional diagnostic sector
at the department , new
educational stuff was hired
in the early 60s: Dr D.
Mitkov, PhD, Dr D. Iluchev,
PhD and later Dr J. Valkov,
PhD and Dr C. Lambreva –
Ljuckanova.
In Early 70s as a consequence
of integrated education
in pathophysiology and pathologic
anatomy and the development
of functional diagnostic
in Pathophysiology Dept.,
several more people became
a part of the department
stuff: Dr St. Bonev, PhD,
Dr M. Gerginova, Dr M. Ovanesjan,
Dr A. Karova, Dr Ivan Yanev,
PhD and Dr St. Kostianev,
DMSc. During the period
of 1978 – 1991 a a branch
of Pathophysiology Dept.
existed in Pazardzik, headed
by Assoc. Prof, D. Iluchev,
DMSc and Ass. Prof. Dr P.
Ilieva, Dr P. Serafimova,
Dr D. Genova and Dr A. Hristova.
After the closure of the
branch all the stuff were
transferred to the main
department in Plovdiv. The
newest people in the department
are Dr B. Marinov, PhD –
Ass. Prof. since 2001, Dr
Mandadzhieva – Ass. Prof.
since 2004 and Dr Kiril
Terziyski – on a PhD research
since 2004.
The
first lectures in pathophysiology
(3 hours weekly) took place
in the city cinema hall.
Pathophysiology education
in MU – Plovdiv combines
experimental and clinical
– functional approaches
in functional pathophysiology.
It is a merit of the department
founder and the first Ass.
Prof.s in it. In that time
a practice to carry out
a part of the practical
education in the clinical
departments was initiated.
In the 60s pathophysiology
education enlarges from
2 to 3 ….. and the practical
sessions are increased to
90 hours. For the first
time in Bulgaria a methodology
of investigating not only
the pathophysiology of disease,
but also the pathophysiology
of the patient, was introduced
in the department. At that
time the results from the
functional diagnostic testing
– PFT, BGA, CPET, were for
the first time used in the
educational process.
The department plays a significant
role in the postgraduate
education of young doctors
in different clinics at
MU performing seminar and
lection sessions. In the
70s a new method of machine-programmed
self-education and test
self-examination was introduced.
It helped also checking
the connection student-teacher.
For the first time in Bulgaria
new visual and multimedia
methods of education were
introduced. Three new educational
halls and a hall for practical
demonstrations were created.
All the available functional
diagnostic laboratory potential
is used as a part of the
education. Voluntary courses
in pathobiochemistry and
functional diagnostic are
carried out in co-operation
with other departments.
From
its very beginning to our
days the department develops
an intensive functional
diagnostic work.
1. In the area of liver
puncture biopsy and capillaryscopy
(L. Telcharov)
2. Pulmonary function, blood-gas
and acid-base diagnostic
(I. Kirin, D. Iluchev, I.
Yanev, St. Kostianev, M.Gerginova,
M. Ovanesjan, A. Karova,
B. Marinov)
3. Diagnostic activities
in the area of functional
pulmonary diagnostics.
The
main scientific areas of
interest in the first 20
years were:
1.
Biopuncture method in biology
and medicine (Prof. L.Telcharov)
2. Alteration in leukocyte
number in pulmonary and
interoreceptive irritation
(Prof. I. Kirin)
3. Influence of Cortisone
and ACTH on the higher activity
of the nervous system.(
Prof. N. Nikolov)
4. Investigating some of
liver functions in disturbance
in higher activity of the
nervous system (B. Kjutjukchiev).
In
the 60s and 70s the main
scientific investigations
of the department were in
the area of: 1. Assessment
of evolution of chronic
pulmonary insufficiency
(stages, degrees and classification)
in patients with chronic
non-specific pulmonary diseases
(I. Kirin) and 2. Investigation
of the pathogenesis and
therapy of lipid dystrophy
of the liver in experimental
alcohol-induced intoxication
(Prof. D. Mitkov).
In the 80s the 2 main areas
of research of Pathophysiology
Dept., Plovdiv, were: 1.
Pathogenesis of liver encephalopathy
– under the supervision
of Prof. D. Mitkov and 2.
Pulmonary function testing
and acid-base status under
physiological and pathological
conditions – D. Iluchev,
D. Yanev, St. Kostianev,
M. Gerginova, M. Ovanesyan,
A. Karova, D. Genova, A.Hristova.
In the first area of research
scientific data of international
value were the role of some
fatty acids in the pathogenesis
of hepatic encephalopathy
(doctoral research of D.
Mitkov, 1989).
